Product name: LyoMorph-Q DPYD direct-SNP kit
Product code (SKU): SD_PGX_00001
Format: qPCR - lyophilized and inhibitor-tolerant (standard). Also provided in liquid format.
Potential use cases / info: The shard-dx™ DPYD kit may allow for rapid detection of the four clinically recognised SNPs in under 1 hour. The assay requires the use of K2 EDTA tubes for blood collection or saliva can be used extraction-free with shard-dx™ recommended tubes that are provided with the kit as an option. The kit can also be utilised with extracted gDNA from blood, swab or saliva. Detection of DPYD SNPs may play a role in detecting potential toxicity to 5-FU chemotherapy for individuals.
Development status: Beta launch. Multiplex optimisation in finalisation.
Targets (Reaction 1 - allele 1):
- DPYD [c.1129-5923C>G] (FAM)
- DPYD [c.1679T>G] (HEX)
- DPYD [c.1905+1G>A] (ATTO 647)
- DPYD [c.2846A>T] (ATTO 590)
Targets (Reaction 2 - allele 2):
- DPYD [c.1129-5923 wild-type] (FAM)
- DPYD [c.1679 wild-type] (HEX)
- DPYD [c.1905+1 wild-type] (ATTO 647)
- DPYD [c.2846 wild-type] (ATTO 590)
Limit of Detection - copies (95%): ≤100 planned
Detection method: Probe
Sample type: gDNA, whole blood (direct), saliva (direct), swab (direct)
Reactions: 48
Shipping: Ambient
Number of mastermixes: 1
Number of reactions required per sample: 2
Positive control inclusion: Yes
Regulatory status: Research Use Only (RUO)
BETA launch program: Join the shard-dx™ beta access program to generate cutting-edge kits alongside us. Find out more on the launch programs definition section on each custom page and product page.

Product name: LyoMorph-Q RNR1 direct-SNP kit
Product code (SKU): SD_PGX_00002
Format: qPCR - lyophilized and inhibitor-tolerant (standard)
Potential use cases / info: The shard-dx™ RNR1 kit utilises saliva (direct) or plasma (direct) and requires the use of shard-dx™ collection tubes for saliva and K2 EDTA tubes for plasma processing. Detection of RNR1 SNPs may play a role in detecting potential ototoxicity to some antibiotics for individuals. Detection of the SNPs may be useful to determine parents hereditary risk of toxicity to some antibiotics as a screening tool. This test may be performed in a lab or is compatible with point-of-care by producing results in a rapid time frame without sample pre-processing in as few as 2 pipetting steps.
Development status: Beta launch. Multiplex optimisation in finalisation.
Targets (Reaction 1):
- RNR1 [m.1555A>G] (FAM)
- RNR1 [m.1494C>T] (FAM)
- RNR1 [m.1095T>C] (HEX)
- RNase P [internal control] (ATTO 647)
Total typical qPCR run time (machine-dependant): < 60 minutes
Limit of Detection - copies (95%): 200 copies - approximately 0.2 cells
Detection method: Probe
Sample type: direct saliva collected in shard-dx™ prescribed tubes or plasma
Reactions: 48
Shipping: Ambient
Number of mastermixes: 1
Number of reactions required per sample: 1
Positive control inclusion: Yes
Regulatory status: Research Use Only (RUO)
Beta-launch program: Join the shard-dx™ beta launch program to generate cutting-edge kits alongside us. Find out more on the launch programs definition section on each custom page and product page.